A number of factors may contribute to depression including being overweight, low self-esteem, stress and anxiety.[34] Endorphins act as a natural pain reliever and antidepressant in the body.[35] Endorphins have long been regarded as responsible for what is known as "runner's high", a euphoric feeling a person receives from intense physical exertion.[36] However, recent research[16][17] indicates that anandamide may possibly play a greater role than endorphins in "runner's high". When a person exercises, levels of both circulating serotonin and endorphins are increased.[37] These levels are known to stay elevated even several days after exercise is discontinued, possibly contributing to improvement in mood, increased self-esteem, and weight management.[36] Exercise alone is a potential prevention method and/or treatment for mild forms of depression.[38]
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